Proven Sensitivity of >99% With Early Detection

INSTI® has the same CPT code* for reimbursement at the same rate as lateral flow tests that take multiple times longer to conduct. Increased testing can equate to increased reimbursement.In a low HIV prevalence setting, over 95% of subjects are expected to receive a negative result without needing a confirmatory test.

INSTI® as Test 1 provides a result 20 to 40 minutes sooner than lateral flow technology, reducing patient anxiety and freeing up provider resources to complete other billable or administrative tasks.

People living with diagnosed HIV in the UK can expect a near-normal life expectancy, particularly if they are diagnosed promptly due to effective anti-retroviral treatment (ART). The increasing numbers of people living with HIV means that the substantial costs of providing HIV specialist treatment and care are rising.

The estimated annual cost for treatment and care is £858 million. If the estimated 4,000 UK-acquired infections diagnosed in 2011 had been prevented, £1.9 billion in lifetime treatment and clinical care costs would have been saved.

A recent study evaluated INSTI®, the instant result HIV test, compared to another 30 minute rapid test and ELISA laboratory test. (n=981 patients and 43 family physicians) Papadima, D. et al.

+ 94.6% physicians were satisfied with the time required to perform INSTI® (reliable negative result after 5 minutes) vs the other rapid test (reliable negative result after 30 minutes).

+ 84.8% of physicians preferred the instant result rapid test.+ Nearly 6 times as many patients opted for the 1 minute INSTI® test over the 30 minute point-of-care test.

+ Physicians in primary care settings preferred the less time-consuming INSTI® method over the 30 minute rapid test.

An HIV Testing Algorithm is defined as the testing steps required to obtain an HIV diagnosis. Tests get listed in the sequence that they should be performed, starting with the Screening Test (Test 1) for the initial screen, followed by a Confirmatory Test (Test 2) if the first test shows a reactive result. A “Tiebreaker” (Test 3) is required if Test 1 and Test 2 provide discordant results. An HIV positive status should be based on the outcome of two or more tests; screen and confirmatory.

In this study, the multi-test rapid testing algorithm increased the positive predictive values of rapid testing to 100% (compared to 86.4% for a single rapid test), giving providers, clients, and HIV counselors timely information about a client’s HIV-positive serostatus. The time between testing and receipt of rapid test algorithm results was, on average, 8 days shorter than laboratory-based confirmatory testing.

The rapid testing algorithm reduced false positive results by 6.2% and agreed with whole blood laboratory testing results 99.5% of the time. Improved referral to care compared to traditional HIV screening occurs when immediate referral is based on an algorithm that uses a second, different rapid test to verify the positive results of the first rapid test. Collection of whole blood for confirmatory testing is not essential and contributes to difficulties in linking individuals to care.